Our rabbit and mouse model
1. How does IVH affect ependymal cilia and how can ciliary injury be reversed?
TEM of ependymal cilia in a 7 day premature kit without IVH.
Area of damage: IVH (SEM)
TEM of ependymal cilia in a 7 day premature kit with IVH.
2. How can we reverse post-IVH hydrocephalus in rabbit and mouse model?
3. How does IVH impact interneuron neurogenesis and cortical interneruons in preterm animals with IVH and what are the underlying cellular and molecular mechanisms?
4. How does IVH disrupt the blood brain barrier, underlying mechanisms and how this can be reversed to the benefit of newborns?