Publications

2016–2020

Ballabh, P. de Vries, L. White matter injury in infants with Intraventricular hemorrhage: Mechanisms and therapies. Nature Neurology Review. In Press 2020.

Klebe D, Tibrewal M, Sharma DR, Vanaparthy R, Krishna S, Varghese M, Cheng B, Mouton PR, Velíšková J, Dobrenis K, Hof PR, Ballabh P. Reduced Hippocampal Dendrite Branching, Spine Density and Neurocognitive Function in Premature Rabbits, and Reversal with Estrogen or TrkB Agonist Treatment. Cerebral Cortex. 2019 Dec 17;29(12):4932–4947. PMID 30877788.

Dohare P, Kidwai A, Kaur J, Singla P, Krishna S, Klebe D, Zhang X, Hevner R, Ballabh P. GSK3β Inhibition Restores Impaired Neurogenesis in Preterm Neonates With Intraventricular Hemorrhage. Cerebral Cortex. 2019 Jul 22;29(8):3482–3495. PMID 30192926.

Tibrewal M, Cheng B, Dohare P, Hu F, Mehdizadeh R, Wang P, Zheng D, Ungvari Z, Ballabh P. Disruption of Interneuron Neurogenesis in Premature Newborns and Reversal with Estrogen Treatment. J Neurosci. 2018 Jan 31;38(5):1100–1113. PMID 29246927.

Panda S, Dohare P, Jain S, Parikh N, Singla P, Mehdizadeh R, Klebe DW, Kleinman G, X Cheng B, Ballabh P. Estrogen treatment reverses prematurity-induced disruption in cortical interneuron population. Journal of Neuroscience. 2018 Aug 22;38(34):7378–7391. PMID 30037831.

Dohare P, Cheng B, Ahmed E, Yadala V, Singla P, Thomas S, Kayton R, Ungvari Z, Ballabh P. Glycogen synthase kinase-3β inhibition enhances myelination in preterm newborns with intraventricular hemorrhage, but not recombinant Wnt3A. Neurobiol Dis. 2018 Jun 22;118:22. PMID 29940337.

Dohare P, Zia MT, Ahmed E, Ahmed A, Yadala V, Schober AL, Ortega JA, Kayton R, Ungvari Z, Mongin AA, Ballabh P. AMPA-Kainate Receptor Inhibition Promotes Neurologic Recovery in Premature Rabbits with Intraventricular Hemorrhage. J Neurosci. 2016 Mar 16;36(11):3363–77. PMID 26985043.

Vinukonda G, Dohare P, Arshad A, Zia MT, Panda S, Korumilli R, Kayton R, Hascall VC, Lauer ME, Ballabh P. Hyaluronidase and Hyaluronan Oligosaccharides Promote Neurological Recovery after Intraventricular Hemorrhage. J Neurosci. 2016 Jan 20;36(3):872–89. doi: 10.1523/JNEUROSCI.3297-15.2016. PMID 26791217.

Vinukonda G, Hu F, Mehdizadeh R. Kayton R, Ballabh P. Epidermal growth factor preserves myelin and promotes astrogliosis after intraventricular hemorrhage. Glia. 2016 Jul 29. doi: 10.1002/glia.23037. PMID 27472419.

Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T,
Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019 Jun;24:101192. doi: 10.1016/j.redox.2019.101192. Epub 2019 Apr 10. PMID: 31015147

Fulop GA, Ramirez-Perez FI, Kiss T, Tarantini S, Valcarcel Ares MN, Toth P, Yabluchanskiy A, Conley SM, Ballabh P, Martinez-Lemus LA, Ungvari Z, Csiszar A. IGF-1 deficiency Promotes Pathological Remodeling of Cerebral Arteries: A Potential Mechanism Contributing to the Pathogenesis of Intracerebral Hemorrhages in Aging. J Gerontol A Biol Sci Med Sci. 2019 Mar 14;74(4):446–454. doi: 10.1093/gerona/gly144. PMID 29931048.

Valcarcel-Ares MN, Tucsek Z, Kiss T, Giles CB, Tarantini S, Yabluchanskiy A, Balasubramanian P, Gautam T, Galvan V, Ballabh P, Richardson A, Freeman WM, Wren JD, Deak F, Ungvari Z, Csiszar A. Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline. J Gerontol A Biol Sci Med Sci. 2019 Mar 14;74(4):446–454. doi: 10.1093/gerona/gly127. PMID 29893815.

2011–2015

Arshad A, Vose LR, Vinukonda G, Hu V, Yoshikawa K, Csiszar A, Brumberg J, Ballabh P. Extended production of cortical interneurons into the third trimester of human gestation. Cerebral cortex. 2015 Apr 16. PMID: 25882040.

Ballabh P, LaGamma EF. Strategies for working with a preterm rabbit model of glycerol-induced intraventricular hemorrhage: strengths and limitations. Pediatr Res. 2014 Nov;76(5):495–6. PMID 25105256.

Ballabh P. Pathogenesis and prevention of intraventricular hemorrhage. Clin Perinatol. 2014 Mar;41(1):47–67 PMID 24524446. (Review article)

Vose LR, Vinukonda G, Diamond D, Korumilli R, Hu F, Zia MT, Hevner R, Ballabh P. Prenatal betamethasone does not affect glutamatergic or GABAergic neurogenesis in preterm newborns. Neuroscience. 2014 Jun 13;270:148–57. doi: 10.1016/j.neuroscience.2014.04.009. Epub 2014 Apr 13. PMID 24735821.

Vose LR, Vinukonda G, Jo S, Miry O, Diamond D, Korumilli R, Arshad A, Zia MT, Hu F, Kayton RJ, La Gamma EF, Bansal R, Bianco AC, Ballabh, P. Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage. J Neurosci. 2013 Oct 30;33(44):17232–46. PMID 24174657.

Malik S, Vinukonda G, Vose LR, Diamond D, Bhimavarapu BB, Hu F, Zia MT, Hevner R, Zecevic N, Ballabh P. Neurogenesis continues in the third trimester of pregnancy and is suppressed by premature birth. J Neurosci. 2013 Jan 9;33(2):411–23. PMID 23303921.

Buser JR, Maire J, Riddle A, Gong X, Nguyen T, Nelson K, Luo NL, Ren J, Struve J, Sherman LS, Miller SP, Chau V, Hendson G, Ballabh P, Grafe MR, Back SA. Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants. Ann Neurol. 2012 Jan;71(1):93–109. PMID 22275256.

Vinukonda G, Hu F, Upreti C, Ungvari Z, Zia MT, Stanton PK, Ballabh P. Novel organotypic in vitro slice culture model for intraventricular hemorrhage of premature infants. J Neurosci Res. 2012 Nov;90(11):2173–82. PMID 22806625.

Vinukonda G, Zia MT, Bhimavarapu BB, Hu F, Feinberg M, Bokhari A, Ungvari Z, Fried VA, Ballabh P. Intraventricular hemorrhage induces deposition of proteoglycans in premature rabbits, but their in vivo degradation with chondroitinase does not restore myelination, ventricle size and neurological recovery. Exp Neurol. 2013 Sep;247:630–44. PMID 23474192.

Dummula K, Vinukonda G, Chu P, Xing Y, Hu F, Mailk S, Csiszar A, Chua C, Mouton P, Kayton RJ, Brumberg JC, Bansal R, Ballabh P. Bone morphogenetic protein inhibition promotes Neurological recovery after intraventricular hemorrhage. J Neurosci. 2011 Aug 24;31(34):12068–82. PubMed. PMID:21865450; PubMed Central PMCID: PMC3167068.

Tucsek Z, Toth P, Tarantini S, Sosnowska D, Gautam T, Warrington JP, Giles CB, Wren JD, Koller A, Ballabh P, Sonntag WE, Ungvari Z, Csiszar A. Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice. J Gerontol A Biol Sci Med Sci. 2014 Nov;69(11):1339–52. PMID 24895269.

Toth P, Tarantini S, Tucsek Z, Ashpole NM, Sosnowska D, Gautam T, Ballabh P, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and down regulation of NADPH oxidase. Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H299–308. PMID 24322615.

Toth P, Tarantini S, Davila A, Valcarcel-Ares MN, Tucsek Z, Varamini B, Ballabh P, Sonntag WE, Baur JA, Csiszar A, Ungvari Z. Purinergic glio-endothelial coupling during neuronal activity: role of P2Y1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex. Am J Physiol Heart Circ Physiol. 2015 ;309(11):H1837–45. doi: 10.1152/ajpheart.00463.2015. Epub 2015 Oct 9. PMID 26453330.

Bailey-Downs LC, Mitschelen M, Sosnowska D, Toth P, Pinto JT, Ballabh P, Valcarcel-Ares MN, Farley J, Koller A, Henthorn JC, Bass C, Sonntag WE, Ungvari Z, Csiszar A. Liver-Specific Knockdown of IGF-1 Decreases Vascular Oxidative Stress Resistance by Impairing the Nrf2-Dependent Antioxidant Response: A Novel Model of Vascular Aging. J Gerontol A Biol Sci Med Sci. 2011 Oct 21. PMID 21602469.

Ungvari Z, Bailey-Downs L, Sosnowska D, Gautam T, Koncz P, Losonczy G, Ballabh P, de Cabo R, Sonntag WE, Csiszar A. Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response. Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H363–72. Epub 2011 May 20. PMID 21602469.

Ungvari Z, Bailey-Downs L, Gautam T, Jimenez R, Losonczy G, Zhang C, Ballabh P, Recchia FA, Wilkerson DC, Sonntag WE, Pearson K, de Cabo R, Csiszar A. Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia. Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1133–40. Epub 2011 Jan 7. PMID 21217061.

2004–2010

Vinukonda G, Csiszar, A, Hu F, Dummula K, Pandey NK, Zia MT, Ferreri, NR, Ungvari, Z, LaGamma, EF, Ballabh, P. Neuroprotection in intraventricular hemorrhage by cox-2 inhibition: EP1 receptor and TNF-α are downstream mediators of brain injury. Brain 2010 Aug;133(Pt 8):2264–802. PMID 20488889.

Chua C, Chahboune H, Braun A, Dummula K, Chua CE, Yu J, Ungvari Z, Sherbany A, Hyder F, Ballabh P. Consequences of intraventricular hemorrhage in a rabbit pup model. Stroke 2009 Oct;40(10):3369–77. PMID 19661479.

Vinukonda G. Csiszar, A. Hu F, Dummula K, Pandey NK, Zia MT, Ferreri, NR, Ungvari, Z, LaGamma, EF, Ballabh, P. Effect of prenatal glucocorticoid on the vasculature of the developing brain. Stroke. 2010 Aug;41(8):1766–73. PMID 20616316.

Ballabh P, Xu H, Hu F, Xu H, Braun A, Ungvari Z. Csiszar A, Goldman S, Nedergaard M. Angiogenic inhibition reduced germinal matrix hemorrhage. Nature Medicine 2007 Apr;13(4):477–85. PMID 17401377. (Cover page article).

Braun A, Xu H, Kocherlakota P, Siegel D, Ungvari Z. Csiszar A , Nedergaard M, Ballabh P. Paucity of pericytes in germinal matrix vasculature. J Neurosci 2007 Oct 31; 27(44):12012–12024. PMID 17978043.

Ballabh P, Braun A, Nedergaard M. Recent insights in blood brain barrier: an overview. Structure, regulation, modulating factors and clinical implications. Neurobiology of Disease 2004;16:1–13.